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自家培養真皮を用いた口蓋裂手 術 動物実験をもとに、倫理委員会承認後 臨床応用を開始した. 文献 Improvement of the maxillary bone growth suppression in the cleft palate operation with cultured dermal substitute: animal experiment and patient reports in preliminary clinical application.Improvement of the maxillary bone growth suppression in the cleft palate operation with cultured dermal substitute: animal experiment and patient reports in preliminary clinical application. Kurokawa N, Ueda K, Kuroyanagi Y. J Plast Reconstr Aesthet Surg. In press. Application of cultured dermal substitute for amelioration of maxillary bone growth suppression after cleft palate operation in rats.Application of cultured dermal substitute for amelioration of maxillary bone growth suppression after cleft palate operation in rats. Kurokawa N, Ueda K, Tsuji M, Kuroyanagi Y. J Artif Organs. 2008;11(4):216-20.
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【臨床応用】 生後３ヶ月：口唇形成術 cleft margin flap の余剰部を採取 線維芽胞の冷凍保存 自家培養真皮の作成 北里大学 人工皮膚開発研究セン ター 生後 1 年 6 ヵ月： 口蓋形成術
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自家培養真皮の貼付（口腔側） ：自家培養真皮
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術中に口蓋床を作成し、自家 培養真皮の固定に利用。
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術後 2 年半の状態 術前 術後
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