"Bone" and "Marrow": neighbors or family? 1. Asada N, *Katayama Y, Sato M, Minagawa K, Wakahashi K, Kawano H, Kawano Y, Sada A, Ikeda K, Matsui T, Tanimoto M. Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells. Cell Stem Cell 12: 737-747, 2013. 2. Sato M, Asada N, Kawano Y, Wakahashi K, Minagawa K, Kawano H, Sada A, Ikeda K, Matsui T, *Katayama Y. Osteocytes regulate primary lymphoid organs and fat metabolism. Cell Metabolism 18: 749-758, 2013. 3. Katayama Y, Battista M, Kao WM, Hidalgo A, Peired AJ, Thomas SA, *Frenette PS. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 124: 407-421, 2006. 4. Katayama Y, *Frenette PS. Galactocerebrosides are required postnatally for stromal -dependent bone marrow lymphopoiesis. Immunity 18: 789-800, 2003. (*corresponding author) 研究科セミナー "Bone" and "Marrow": neighbors or family? 講師：片山　義雄 博士（Dr. Yoshio Katayama） 　　 神戸大学医学部附属病院血液内科　講師 　　　　 (Junior Associate Professor, Hematology, Kobe University Hospital) 日時： 11月10（木） /Thu., Nov. 10 15：00～16：00 会場： 大セミナー室/ Large Seminar Room 要旨 　臓器連関による機能的ネットワークが近年さかんに研究されるようになってきました。我々はこれまでに、造血システムが脳•神経系や骨代謝などによる制御を受けて恒常性を保っていることを報告してきました（ref. 1-4）。本セミナーでは、このネットワークの一時的歪みの臨床応用例と不可逆的歪みによる疾患発症について紹介することで、「骨」と「髄」の切っても切れない関係をお話したいと思います。 Inter-organ network is one of the hot topics in the research field. We have reported that homeostatic regulation of hematopoietic system is supported by other organs such as nervous system and bone metabolism (ref. 1-4). In this seminar, I would like to discuss the intimate relationship between “bone” and “marrow” through an introduction of a clinical application of transient deviation and a disease by irreversible deviation of this network.

【参考論文】 1. Asada N, *Katayama Y, Sato M, Minagawa K, Wakahashi K, Kawano H, Kawano Y, Sada A, Ikeda K, Matsui T, Tanimoto M. Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells. Cell Stem Cell 12: 737-747, 2013. 2. Sato M, Asada N, Kawano Y, Wakahashi K, Minagawa K, Kawano H, Sada A, Ikeda K, Matsui T, *Katayama Y. Osteocytes regulate primary lymphoid organs and fat metabolism. Cell Metabolism 18: 749-758, 2013. 3. Katayama Y, Battista M, Kao WM, Hidalgo A, Peired AJ, Thomas SA, *Frenette PS. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 124: 407-421, 2006. 4. Katayama Y, *Frenette PS. Galactocerebrosides are required postnatally for stromal -dependent bone marrow lymphopoiesis. Immunity 18: 789-800, 2003. (*corresponding author)